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GLASS

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GPCR

Name	Motilin receptor
Species	Homo sapiens (Human)
Gene	MLNR
Synonym	GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR motilin receptor MOT-R [ Show all ]
Disease	Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder Pain Dyspepsia Diarrhea Delayed gastric emptying; Gastroparesis Constipation Gastroparesis [ Show all ]
Length	412
Amino acid sequence	MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProt	O43193
Protein Data Bank	N/A
GPCR-HGmod model	O43193
3D structure model	This predicted structure model is from GPCR-EXP O43193.
BioLiP	N/A
Therapeutic Target Database	T62306
ChEMBL	CHEMBL2203
IUPHAR	297
DrugBank	BE0003521

Ligand

Name	CHEMBL1077578
Molecular formula	C17H19NO2S
IUPAC name	7-(benzenesulfonylmethyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
Molecular weight	301.404
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.5
Synonyms	SCHEMBL1789401 7-(phenylsulfonylmethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine BDBM50415667 ICKFLQAGATZMFM-UHFFFAOYSA-N
Inchi Key	ICKFLQAGATZMFM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19NO2S/c19-21(20,17-4-2-1-3-5-17)13-14-6-7-15-8-10-18-11-9-16(15)12-14/h1-7,12,18H,8-11,13H2
PubChem CID	46882673
ChEMBL	CHEMBL1077578
IUPHAR	N/A
BindingDB	50415667
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<12589.2 nM	PMID19804969	BindingDB,ChEMBL

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