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Name | C-X-C chemokine receptor type 1 |
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Species | Homo sapiens (Human) |
Gene | CXCR1 |
Synonym | CDw128a IL8RA IL-8R A IL-8 receptor type I IL-8 receptor type 1 [ Show all ] |
Disease | N/A |
Length | 350 |
Amino acid sequence | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL |
UniProt | P25024 |
Protein Data Bank | N/A |
GPCR-HGmod model | P25024 |
3D structure model | This predicted structure model is from GPCR-EXP P25024. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4029 |
IUPHAR | 68 |
DrugBank | BE0003552 |
Name | CHEMBL451438 |
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Molecular formula | C33H52O8 |
IUPAC name | [(3S,5R,6S,7S,10R,11R,13R,14R,17R)-6,7-diacetyloxy-5,11-dihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-yl] acetate |
Molecular weight | 576.771 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | 5.1 |
Synonyms | 5alpha-Cholesta-8-ene-3beta,5,6alpha,7alpha,11alpha-pentol 3,6,7-triacetate BDBM50269197 cholest-8-ene-3beta,5alpha,6alpha,7alpha,10alpha-pentol 3,6,7-triacetate |
Inchi Key | ICLBGXNCCPNRNO-GKZMMRKQSA-N |
Inchi ID | InChI=1S/C33H52O8/c1-18(2)10-9-11-19(3)24-12-13-25-27-28(26(37)17-31(24,25)7)32(8)15-14-23(39-20(4)34)16-33(32,38)30(41-22(6)36)29(27)40-21(5)35/h18-19,23-26,29-30,37-38H,9-17H2,1-8H3/t19-,23+,24-,25+,26-,29+,30+,31-,32-,33+/m1/s1 |
PubChem CID | 10555185 |
ChEMBL | CHEMBL451438 |
IUPHAR | N/A |
BindingDB | 50269197 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 5500.0 nM | PMID10843593 | BindingDB,ChEMBL |
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