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GPCR

NameAlpha-2B adrenergic receptor
SpeciesDidelphis virginiana (North American opossum)
GeneADRA2B
SynonymAlpha-2B adrenoceptor
Alpha-2B adrenoreceptor
Alpha-2BAR
DiseaseN/A for non-human GPCRs
Length382
Amino acid sequenceAIAAVITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRHTWCEVYLALDVLFCTSSIVHLCAISLDRYWSVSRALEYNSKRTPRRIKGIILTVWLIAAFISLPPLIYKGDKGKKPGGRPQCKLNEEAWYILSSSIGSFFAPCLIMILVYLRIYLIAKRRNRQGPHGKQAPGDGDTGPSALGGTSTISKLPPSILPAVGEANGHSKPPGEREGGEQMGDPTSPSTPPNQSSVGPEDGSQKQEEEEEEEEEEEEECGPPAPPTSSSLQGTPNFQPSQGSQVLATLRGQVLLARGPASLGLQPWRRRTQMNREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPQHCKVPHGLF
UniProtO77715
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHARN/A
DrugBankN/A

Ligand

Nameprazosin
Molecular formulaC19H21N5O4
IUPAC name[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
Molecular weight383.408
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP2.0
SynonymsBSPBio_001036
NCGC00024324-02
CHEMBL2
NCI60_002417
DivK1c_000375
[ Show all ]
Inchi KeyIENZQIKPVFGBNW-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
PubChem CID4893
ChEMBLCHEMBL2
IUPHAR503
BindingDB29568
DrugBankDB00457

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki7.4 nMPMID2894455BindingDB
Ki7.6 nMPMID2894455BindingDB
Ki117.48 nMPMID7908054BindingDB
Ki131.82 nMPMID7908054BindingDB

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