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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	prazosin
Molecular formula	C19H21N5O4
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
Molecular weight	383.408
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	2.0
Synonyms	2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline KBio2_002944 ZINC95616601 KBioGR_000965 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone AB00053528_21 Minipress BCP14556 NCGC00016740-05 BRD-K49111258-001-02-8 NCGC00016740-13 C19H21N5O4 PRAZOSIN, Prazosin Hydrochloride NCGC00024324-06 CTK7A0338 Prestwick0_000947 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- DSSTox_RID_83272 SCHEMBL26524 HMS1362D17 Spectrum5_001365 1-(3-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride IDI1_000375 Tox21_113646 Justac Vasoflex (TN) 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine KBio2_006438 [3H]-Pratsiol KS-00002WRN AKOS000310009 MolPort-000-891-036 Bio1_000854 NCGC00016740-08 BRN 0768345 NCGC00016740-18 CHEBI:8364 Prazosine NCGC00024324-09 Prestwick3_000947 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- (8CI) FT-0630457 SPBio_001297 HMS2089G09 ST24038261 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine KBio2_000376 XRA 2-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine KBio3_001721 [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone AB00053528-19 LS-140002 BBL028799 NCGC00016740-03 Bio2_000838 NCGC00016740-11 BSPBio_002221 Prazosin (INN) NCGC00024324-04 CP-12299 Prazosinum [INN-Latin] NINDS_000375 DSSTox_CID_29008 SBB032268 Prazocin GTPL5385 Spectrum3_000551 HY-B0193 TNP00312 19216-56-9 Tox21_113646_1 2-[4-(2-Furoyl)-1-piperazinyl]-6,7-dimethoxy-4-quinazolinamine # KBio2_003870 [3H]-Furazosin 4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone KBioSS_000376 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone AC1L1J6T Minipress (TN) BDBM29568 NCGC00016740-06 BRD-K49111258-003-05-7 NCGC00016740-14 CAS-19216-56-9 Prazosina NCGC00024324-07 D08411 Prestwick1_000947 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- (9CI) DTXSID4049082 SMP1_000063 HMS1792D17 Spectrum_000822 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) piperazine IDI1_002113 KB-207710 W-107722 2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine KBio3_000731 [3H]-Prazosin 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)piperazin-1-yl]quinazoline L000666 AN-15618 NCGC00016740-01 Bio1_001343 NCGC00016740-09 BSPBio_000914 NCGC00016740-19 Prazosine [INN-French] NCGC00024324-10 DB00457 Quinazoline, 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)- Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-(8CI) Furazosin SPBio_003073 (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-piperazin-1-yl)(furan-2-yl)methanone HMS3403D17 STK301545 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-(2-furoyl)piperazine 2-(4-(2-FUROYL)-1-PIPERAZINYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE KBio2_001302 Z275127478 237P844 KBioGR_000376 [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone AB00053528_20 MCULE-8104643269 BCBcMAP01_000227 NCGC00016740-04 BPBio1_001006 NCGC00016740-12 C07368 Prazosin [INN:BAN] NCGC00024324-05 CS-2088 Pressin Oprea1_314778 DSSTox_GSID_49082 SBI-0051487.P003 H961 Spectrum4_000483 1-(3-Amino-6,7-dimethoxy-2- quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride Hypovase (TN) Tocris-0623 UNII-XM03YJ541D 2-[4-(2-Furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline KBio2_005512 [3H]-Minipress 5-25-13-00365 (Beilstein Handbook Reference) KBioSS_001302 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-furan-2-ylmethanone AF-0052 MLS006011888 Bio1_000365 NCGC00016740-07 BRD-K49111258-003-16-4 NCGC00016740-15 CAS-19237-84-4 Prazosina [INN-Spanish] NCGC00024324-08 D0WV3U Prestwick2_000947 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- EINECS 242-885-8 SMR001550197 HMS1990D17 ST075549 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine IENZQIKPVFGBNW-UHFFFAOYSA-N KBio1_000375 XM03YJ541D 2-[4-(Furan-2-Ylcarbonyl)piperazin-1-Yl]-6,7-Dimethoxyquinazolin-4-Amine KBio3_000732 [3H]prazosin AB00053528 Lentopres AN-18022 NCGC00016740-02 Bio2_000358 NCGC00016740-10 BSPBio_001036 NCGC00024324-02 CHEMBL2 Prazosinum NCI60_002417 DivK1c_000375 SB17351 Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-(9CI) GTPL503 Spectrum2_001289 (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone HSDB 3298 TL8001573 1-(4-amino-6,7-dimethoxy-2-quinazolinyl-4-(2-furanylcarbonyl)) piperrazine [ Show all ]
Inchi Key	IENZQIKPVFGBNW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
PubChem CID	4893
ChEMBL	CHEMBL2
IUPHAR	503
BindingDB	29568
DrugBank	DB00457
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<4200.0 nM	PMID12519065	BindingDB,ChEMBL

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