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Name | Motilin receptor |
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Species | Homo sapiens (Human) |
Gene | MLNR |
Synonym | GPR38 G protein-coupled receptor 38 G-protein coupled receptor 38 MTLR1 MTLR [ Show all ] |
Disease | Gastrointestinal disorders; Gastroesophageal reflux disease Irritable bowel syndrome Gastrointestinal disease Gastroesophageal reflux disease Gastric motility disorder [ Show all ] |
Length | 412 |
Amino acid sequence | MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG |
UniProt | O43193 |
Protein Data Bank | N/A |
GPCR-HGmod model | O43193 |
3D structure model | This predicted structure model is from GPCR-EXP O43193. |
BioLiP | N/A |
Therapeutic Target Database | T62306 |
ChEMBL | CHEMBL2203 |
IUPHAR | 297 |
DrugBank | BE0003521 |
Name | CHEMBL1079187 |
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Molecular formula | C25H32N4O2S |
IUPAC name | 4-butyl-N-[3-[(2-methyl-1H-imidazol-5-yl)methyl]-1,2,4,5-tetrahydro-3-benzazepin-7-yl]benzenesulfonamide |
Molecular weight | 452.617 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 4.7 |
Synonyms | BDBM50415673 |
Inchi Key | IEWQTFGFLPFFRK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C25H32N4O2S/c1-3-4-5-20-6-10-25(11-7-20)32(30,31)28-23-9-8-21-12-14-29(15-13-22(21)16-23)18-24-17-26-19(2)27-24/h6-11,16-17,28H,3-5,12-15,18H2,1-2H3,(H,26,27) |
PubChem CID | 46882396 |
ChEMBL | CHEMBL1079187 |
IUPHAR | N/A |
BindingDB | 50415673 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 63.1 nM | PMID19804969 | BindingDB,ChEMBL |
Intrinsic activity | 0.7 - | PMID19804969 | ChEMBL |
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