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GPCR

NameGalanin receptor type 2
SpeciesHomo sapiens (Human)
GeneGALR2
SynonymGAL2 receptor
GAL2-R
GALNR2
GALR-2
DiseaseN/A
Length387
Amino acid sequenceMNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProtO43603
Protein Data BankN/A
GPCR-HGmod modelO43603
3D structure modelThis predicted structure model is from GPCR-EXP O43603.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3176
IUPHAR244
DrugBankN/A

Ligand

NameMLS000584180
Molecular formulaC18H15ClN2O2
IUPAC name2-chloro-3-[4-(dimethylamino)anilino]naphthalene-1,4-dione
Molecular weight326.78
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.3
Synonymscid_260557
NSC-92081
2-chloranyl-3-[[4-(dimethylamino)phenyl]amino]naphthalene-1,4-dione
AC1Q6B4H
HMS2620L09
[ Show all ]
Inchi KeyIFCBGAQTKDYXAL-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H15ClN2O2/c1-21(2)12-9-7-11(8-10-12)20-16-15(19)17(22)13-5-3-4-6-14(13)18(16)23/h3-10,20H,1-2H3
PubChem CID260557
ChEMBLCHEMBL1451772
IUPHARN/A
BindingDB34778
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<14000.0 nM, PubChem BioAssay data setBindingDB,ChEMBL
IC508838.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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