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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanin-concentrating hormone receptor 2
Species	Homo sapiens (Human)
Gene	MCHR2
Synonym	G-protein coupled receptor 145 melanin-concentrating hormone receptor 2 MCHR-2 MCH2R MCH2 receptor MCH2 G protein-coupled receptor 145 MCH-2R MCH receptor 2 GPRv17 GPR145 MCH-R2 [ Show all ]
Disease	N/A
Length	340
Amino acid sequence	MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProt	Q969V1
Protein Data Bank	N/A
GPCR-HGmod model	Q969V1
3D structure model	This predicted structure model is from GPCR-EXP Q969V1.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5038
IUPHAR	281
DrugBank	N/A

Ligand

Name	CHEMBL209510
Molecular formula	C31H31ClFN5
IUPAC name	3-[4-[[(5-chloro-6-fluoro-1H-benzimidazol-2-yl)methylamino]-[1-(cyclopropylmethyl)piperidin-4-yl]methyl]phenyl]benzonitrile
Molecular weight	528.072
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	6.0
Synonyms	BDBM50186793 SCHEMBL12561226 4''-[[(6-chloro-5-fluoro-1H-benzoimidazol-2-ylmethyl)-amino]-(1-cyclopropylmethyl-piperidin-4-yl)-methyl]-biphenyl-3-carbonitrile
Inchi Key	IFIJZCFVDUUXOH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C31H31ClFN5/c32-26-15-28-29(16-27(26)33)37-30(36-28)18-35-31(24-10-12-38(13-11-24)19-20-4-5-20)23-8-6-22(7-9-23)25-3-1-2-21(14-25)17-34/h1-3,6-9,14-16,20,24,31,35H,4-5,10-13,18-19H2,(H,36,37)
PubChem CID	11156790
ChEMBL	CHEMBL209510
IUPHAR	N/A
BindingDB	50186793
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<3000.0 nM	PMID16690312	BindingDB,ChEMBL

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