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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameMLS000391427
Molecular formulaC21H18Cl2N2O3S
IUPAC nameN-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]-4-(oxolan-2-ylmethoxy)benzamide
Molecular weight449.346
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.4
SynonymsMLS003914913
SR-01000716198-2
AKOS034047684
CHEMBL1545848
N-[4-(2,4-dichlorophenyl)-1,3-thiazol-2-yl]-4-[(oxolan-2-yl)methoxy]benzamide
[ Show all ]
Inchi KeyIIWNGLGBKYAGTD-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H18Cl2N2O3S/c22-14-5-8-17(18(23)10-14)19-12-29-21(24-19)25-20(26)13-3-6-15(7-4-13)28-11-16-2-1-9-27-16/h3-8,10,12,16H,1-2,9,11H2,(H,24,25,26)
PubChem CID4544702
ChEMBLCHEMBL1545848
IUPHARN/A
BindingDB97088
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC501072.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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