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GPCR

NameC-X-C chemokine receptor type 2
SpeciesOryctolagus cuniculus (Rabbit)
GeneCXCR2
SynonymCXC-R2
CXCR-2
GRO/MGSA receptor
High affinity interleukin-8 receptor B
IL-8R B
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMQEFTWENYSYEDFFGDFSNYSYSTDLPPTLLDSAPCRSESLETNSYVVLITYILVFLLSLLGNSLVMLVILYSRSTCSVTDVYLLNLAIADLLFATTLPIWAASKVHGWTFGTPLCKVVSLVKEVNFYSGILLLACISVDRYLAIVHATRTMIQKRHLVKFICLSMWGVSLILSLPILLFRNAIFPPNSSPVCYEDMGNSTAKWRMVLRILPQTFGFILPLLVMLFCYVFTLRTLFQAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLTDTLMRTHVIQETCERRNDIDRALDATEILGFLHSCLNPIIYAFIGQKFRYGLLKILAAHGLISKEFLAKESRPSFVASSSGNTSTTL
UniProtP35344
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1075198
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL404661
Molecular formulaC18H17BrFN3O3S
IUPAC name1-[2-[5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl]ethyl]-3-methylsulfonylurea
Molecular weight454.314
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP3.5
Synonyms1-(2-(5-bromo-2-(4-fluorophenyl)-1H-indol-3-yl)ethyl)-3-(methylsulfonyl)urea
BDBM50236296
Inchi KeyASQXPPFKSBAWCP-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H17BrFN3O3S/c1-27(25,26)23-18(24)21-9-8-14-15-10-12(19)4-7-16(15)22-17(14)11-2-5-13(20)6-3-11/h2-7,10,22H,8-9H2,1H3,(H2,21,23,24)
PubChem CID44447944
ChEMBLCHEMBL404661
IUPHARN/A
BindingDB50236296
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC505800.0 nMPMID18308567BindingDB,ChEMBL

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