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Name | Histamine H3 receptor |
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Species | Homo sapiens (Human) |
Gene | HRH3 |
Synonym | HH3R H3R H3 receptor GPCR97 G-protein coupled receptor 97 |
Disease | Obese insulin-resistant disorders Excessive daytime sleepiness Sleep disorders Schizophrenia Pain [ Show all ] |
Length | 445 |
Amino acid sequence | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK |
UniProt | Q9Y5N1 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9Y5N1 |
3D structure model | This predicted structure model is from GPCR-EXP Q9Y5N1. |
BioLiP | N/A |
Therapeutic Target Database | T64765 |
ChEMBL | CHEMBL264 |
IUPHAR | 264 |
DrugBank | BE0000968 |
Name | CHEMBL2048583 |
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Molecular formula | C18H31N5OS |
IUPAC name | 2-(3-methoxypiperidin-1-yl)-5-(4-piperidin-1-ylpiperidin-1-yl)-1,3,4-thiadiazole |
Molecular weight | 365.54 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 3.1 |
Synonyms | BDBM50386357 |
Inchi Key | IJQMPJJDNNFMLK-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C18H31N5OS/c1-24-16-6-5-11-23(14-16)18-20-19-17(25-18)22-12-7-15(8-13-22)21-9-3-2-4-10-21/h15-16H,2-14H2,1H3 |
PubChem CID | 62707526 |
ChEMBL | CHEMBL2048583 |
IUPHAR | N/A |
BindingDB | 50386357 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 37.0 nM | PMID24900450 | BindingDB,ChEMBL |
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