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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(2) dopamine receptor
Species	Rattus norvegicus (Rat)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R Dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61169
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL339
IUPHAR	215
DrugBank	N/A

Ligand

Name	ADTN
Molecular formula	C10H13NO2
IUPAC name	6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol
Molecular weight	179.219
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	1.4
Synonyms	AKOS006328808 cid_11957526 HMS1990C05 KBioSS_002519 NCGC00015291-05 PDSP2_000476 (+)-ADTN 2-aminotetralin-6,7-diol;hydrobromide 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol BPBio1_001127 CTK4J8115 KBio2_002511 LS-175452 NCGC00162147-02 SMR001254097 2,3-Naphthalenediol, 6-amino-5,6,7,8-tetrahydro- 6,7-Adtn GTPL932 KBio3_002989 NCGC00015291-03 PDSP1_000478 2-Amino-6,7-dihydroxytetralin 6-Amino-5,6,7,8-tetrahydro-2,3-naphthalenediol AC1Q79PY BDBM81195 cid_3153 HMS3403C05 L000081 NCGC00015291-06 PDSP2_000807 (+)-ADTN (aminotetralin-6,7-diol) 463A788 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide BSPBio_001023 D0X2NO KBio2_005079 MLS002172466 NCGC00162147-03 SR-01000075362 2,3-Naphthalenediol,6-amino-5,6,7,8-tetrahydro- 6,7-Dihydroxy-2-aminotetralin CHEMBL26736 HMS1792C05 KBioGR_002511 NCGC00015291-04 PDSP1_000820 2-aminotetralin-6,7-diol 6-Amino-5,6,7,8-tetrahydro-naphthalene-2,3-diol Biomol-NT_000003 cMAP_000069 KB-199024 Lopac0_000415 NCGC00162147-01 SCHEMBL3126243 53463-78-8 6-azanyl-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide CCG-204507 FT-0645288 KBio2_007647 NCGC00015291-02 NCGC00162147-04 SR-01000075362-6 2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene 6,7-Dihydroxy-3-chromanamine AC1L1FAH [ Show all ]
Inchi Key	ASXGAOFCKGHGMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2
PubChem CID	3153
ChEMBL	CHEMBL26736
IUPHAR	932
BindingDB	81195
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	700.0 nM	PMID9767652	BindingDB,ChEMBL
Ki	1.07 nM	PMID2531826	BindingDB
Ki	6.1 nM	PMID1356154	BindingDB
Ki	24.0 nM	PMID1356154	BindingDB
Ki	24.91 nM	PMID2531826	BindingDB
Ki	65.7 nM	PMID2136916	ChEMBL
Ki	66.0 nM	PMID2136916	BindingDB
Ki	1370.0 nM	PMID2415793	BindingDB

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