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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Galanin receptor type 2
Species	Homo sapiens (Human)
Gene	GALR2
Synonym	GAL2 receptor GAL2-R GALNR2 GALR-2
Disease	N/A
Length	387
Amino acid sequence	MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProt	O43603
Protein Data Bank	N/A
GPCR-HGmod model	O43603
3D structure model	This predicted structure model is from GPCR-EXP O43603.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3176
IUPHAR	244
DrugBank	N/A

Ligand

Name	MLS000096632
Molecular formula	C16H18N2O5S
IUPAC name	ethyl 2-[4-(pyridin-4-ylmethylsulfamoyl)phenoxy]acetate
Molecular weight	350.389
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	1.6
Synonyms	2-[4-(pyridin-4-ylmethylsulfamoyl)phenoxy]acetic acid ethyl ester ChemDiv2_001984 AKOS000603061 ethyl 2-[4-(pyridin-4-ylmethylsulfamoyl)phenoxy]acetate regid4264959 HMS2502J04 {4-[(Pyridin-4-ylmethyl)-sulfamoyl]-phenoxy}-acetic acid ethyl ester cid_1082996 MLS002541912 BAS 06188254 ethyl 2-[4-(pyridin-4-ylmethylsulfamoyl)phenoxy]ethanoate SMR000073796 2-[4-(4-pyridylmethylsulfamoyl)phenoxy]acetic acid ethyl ester CHEMBL1382898 MCULE-8143442187 AC1LLE85 ethyl (4-{[(4-pyridinylmethyl)amino]sulfonyl}phenoxy)acetate MolPort-002-003-770 BDBM42040 HMS1374K04 ZINC798692 [ Show all ]
Inchi Key	INMOBAGWVIAPNU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C16H18N2O5S/c1-2-22-16(19)12-23-14-3-5-15(6-4-14)24(20,21)18-11-13-7-9-17-10-8-13/h3-10,18H,2,11-12H2,1H3
PubChem CID	1082996
ChEMBL	CHEMBL1382898
IUPHAR	N/A
BindingDB	42040
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<42000.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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