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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesSus scrofa (Pig)
GeneCHRM2
SynonymN/A
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP06199
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4781
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL609382
Molecular formulaC40H54N4O4
IUPAC name2-[3-[cyclohexyl-[6-[cyclohexyl-[3-(1,3-dioxoisoindol-2-yl)propyl]amino]hexyl]amino]propyl]isoindole-1,3-dione
Molecular weight654.896
Hydrogen bond acceptor6
Hydrogen bond donor0
XlogP7.4
Synonyms2-[3-[cyclohexyl[6-[cyclohexyl[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)propyl]amino]hexyl]amino]propyl]isoindole-1,3-dione
Inchi KeyIPFHFZGETVWVEB-UHFFFAOYSA-N
Inchi IDInChI=1S/C40H54N4O4/c45-37-33-21-9-10-22-34(33)38(46)43(37)29-15-27-41(31-17-5-3-6-18-31)25-13-1-2-14-26-42(32-19-7-4-8-20-32)28-16-30-44-39(47)35-23-11-12-24-36(35)40(44)48/h9-12,21-24,31-32H,1-8,13-20,25-30H2
PubChem CID10009514
ChEMBLCHEMBL609382
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
EC5044.98 nMPMID12672239ChEMBL

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