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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Beta-2 adrenergic receptor
Species	Cavia porcellus (Guinea pig)
Gene	Adrb2
Synonym	Beta-2 adrenoceptor Beta-2 adrenoreceptor
Disease	N/A for non-human GPCRs
Length	418
Amino acid sequence	MGHLGNGSDFLLAPNASHAPDHNVTRERDEAWVVGMAIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMNMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWVVSGLTSFLPIQMHWYRATHKDAINCYAEETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAKKQLQKIDRSEGRFHTQNLSQVEQDGRSGHGLRRSSKFYLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSALKAYGNDCSSNSNGKTDYTGEPNVCHQGQEKERELLCEDPPGTEDLVSCPGTVPSDSIDSQGRNYSTNDSLL
UniProt	Q8K4Z4
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5414
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL206100
Molecular formula	C4H5N3O4
IUPAC name	4-(hydroxymethyl)-2-oxido-1,2,5-oxadiazol-2-ium-3-carboxamide
Molecular weight	159.101
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	-0.9
Synonyms	4-(hydroxymethyl)-1,2,5-Oxadiazole-3-carboxamide 2-oxide SCHEMBL429693 CAS-1609 4-hydroxymethyl-2-oxy-furazan-3-carboxylic acid amide CTK8H1175 AKOS023557327 ZINC1484690 158590-73-9 4-hydroxymethyl-3-furoxancarboxamide KB-71654 BDBM50186613 [ Show all ]
Inchi Key	IPHRXVUYWVWSTP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C4H5N3O4/c5-4(9)3-2(1-8)6-11-7(3)10/h8H,1H2,(H2,5,9)
PubChem CID	10103414
ChEMBL	CHEMBL206100
IUPHAR	N/A
BindingDB	50186613
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	86000.0 nM	PMID17845020	BindingDB,ChEMBL

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