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GPCR

NameGalanin receptor type 3
SpeciesHomo sapiens (Human)
GeneGALR3
SynonymGAL3-R
Galnr3
GALR-3
GALR3
GAL3 receptor
DiseaseCognitive disorders
Length368
Amino acid sequenceMADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProtO60755
Protein Data BankN/A
GPCR-HGmod modelO60755
3D structure modelThis predicted structure model is from GPCR-EXP O60755.
BioLiPN/A
Therapeutic Target DatabaseT98494
ChEMBLCHEMBL2731
IUPHAR245
DrugBankN/A

Ligand

NameMLS000717757
Molecular formulaC19H30N2
IUPAC name4-heptyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-imine
Molecular weight286.463
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP5.1
SynonymsAC1LXCS8
SMR000279125
(4-heptyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-ylidene)amine;hydrobromide
BDBM97099
4-heptyl-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-imine;hydrobromide
[ Show all ]
Inchi KeyIRHMEKGTYJBSMM-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H30N2/c1-2-3-4-5-8-14-21-17-12-7-6-10-15(17)19(20)16-11-9-13-18(16)21/h20H,2-14H2,1H3
PubChem CID1799112
ChEMBLN/A
IUPHARN/A
BindingDB97099
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50<1108.0 nMN/ABindingDB

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