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Name | Neuropeptide Y receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | NPY2R |
Synonym | NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor |
Disease | Diabetes Metabolic disorders Obesity |
Length | 381 |
Amino acid sequence | MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV |
UniProt | P49146 |
Protein Data Bank | N/A |
GPCR-HGmod model | P49146 |
3D structure model | This predicted structure model is from GPCR-EXP P49146. |
BioLiP | N/A |
Therapeutic Target Database | T10670 |
ChEMBL | CHEMBL4018 |
IUPHAR | 306 |
DrugBank | BE0002419 |
Name | MLS000685650 |
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Molecular formula | C16H12N2O3S2 |
IUPAC name | (5Z)-3-anilino-5-[(3,4-dihydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one |
Molecular weight | 344.403 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 3 |
XlogP | 4.1 |
Synonyms | (5Z)-3-anilino-5-[(3,4-dihydroxyphenyl)methylidene]-2-sulfanylidene-4-thiazolidinone CHEMBL1575649 (5Z)-3-anilino-5-(3,4-dihydroxybenzylidene)-2-thioxo-thiazolidin-4-one BDBM47430 STL035268 [ Show all ] |
Inchi Key | ATKORQIIELSXJL-ZROIWOOFSA-N |
Inchi ID | InChI=1S/C16H12N2O3S2/c19-12-7-6-10(8-13(12)20)9-14-15(21)18(16(22)23-14)17-11-4-2-1-3-5-11/h1-9,17,19-20H/b14-9- |
PubChem CID | 1630995 |
ChEMBL | CHEMBL1575649 |
IUPHAR | N/A |
BindingDB | 47430 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | <35430.0 nM | , PubChem BioAssay data set | BindingDB,ChEMBL |
EC50 | 26644.0 nM | , PubChem BioAssay data set | BindingDB,ChEMBL |
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