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GPCR

NameAlpha-1A adrenergic receptor
SpeciesOryctolagus cuniculus (Rabbit)
GeneADRA1A
SynonymAlpha-1A adrenoceptor
Alpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMVFLSGNASDSSNCTHPPAPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIISLCVISIDRYIGVSYPLRYPTIVTQRRGLRALLCVWAFSLVISVGPLFGWRQPAPDDETICQINEEPGYVLFSALGSFYVPLTIILAMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAPAGGSGVASAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLKIQCLRRKQSSKHALGYTLHAPSQALEGQHKDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPRGSARITVPKDQSACTTARVRSKSFLQVCCCVGPSTPNPGENHQVPTIKIHTISLSENGEEV
UniProtO02824
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3637
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL322492
Molecular formulaC15H19N3O2S
IUPAC nameN-[5-(1H-imidazol-5-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-1-yl]methanesulfonamide
Molecular weight305.396
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP2.3
SynonymsSCHEMBL7105258
Inchi KeyITBAOQCXPVCRHN-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H19N3O2S/c1-21(19,20)18-14-8-4-7-11-12(14)5-2-3-6-13(11)15-9-16-10-17-15/h4,7-10,13,18H,2-3,5-6H2,1H3,(H,16,17)
PubChem CID9815005
ChEMBLCHEMBL322492
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5019054.6 nMMed Chem Res, (2004) 13:3:134ChEMBL
Efficacy17.0 %PMID15163201, Med Chem Res, (2004) 13:3:134ChEMBL
pD24.72 -PMID15163201ChEMBL

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