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Name | Beta-1 adrenergic receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Adrb1 |
Synonym | adrenergic receptor beta1-adrenoceptor Beta-1 adrenoreceptor Beta-1 adrenoceptor beta-1 adrenergic receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 466 |
Amino acid sequence | MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV |
UniProt | P18090 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3252 |
IUPHAR | N/A |
DrugBank | N/A |
Name | metoprolol |
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Molecular formula | C15H25NO3 |
IUPAC name | 1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol |
Molecular weight | 267.369 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 1.9 |
Synonyms | Leiras Brand of Metoprolol Succinate or Metoprolol Tartrate AB00053499_23 Lopressor, Toprol-xl AstraZeneca Brand of Seloken Metoprolol succinate [ Show all ] |
Inchi Key | IUBSYMUCCVWXPE-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3 |
PubChem CID | 4171 |
ChEMBL | CHEMBL13 |
IUPHAR | 553 |
BindingDB | 25756 |
DrugBank | DB00264 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
ED50 | 0.25 mg.kg-1 | PMID6138435, PMID6142955 | ChEMBL |
Kd | 22.91 nM | PMID27299736, PMID2884312 | BindingDB,ChEMBL |
Kd | 23.0 nM | PMID2884312 | BindingDB |
Ki | 63.1 nM | PMID1968985 | BindingDB |
Ki | 398.11 nM | PMID16759089 | ChEMBL |
Ki | 630.96 nM | PMID16759089 | ChEMBL |
Ki | 2511.89 nM | PMID16759089 | ChEMBL |
Ki | 5011.87 nM | PMID16759089 | ChEMBL |
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