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GPCR

NameGlucose-dependent insulinotropic receptor
SpeciesMus musculus (Mouse)
GeneGpr119
SynonymG protein-coupled receptor 119
G-protein coupled receptor 119
G-protein coupled receptor 2
glucose-dependent insulinotropic receptor
GPCR2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length335
Amino acid sequenceMESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProtQ7TQP3
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5263
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2086650
Molecular formulaC21H28N4O5S
IUPAC nametert-butyl 4-[5-[(4-methylsulfonylphenyl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate
Molecular weight448.538
Hydrogen bond acceptor8
Hydrogen bond donor0
XlogP2.0
Synonymstert-butyl 4-(5-(4-(methylsulfonyl)-benzyloxy)pyrimidin-2-yl)piperazine-1-carboxylate
BDBM50420871
IUCMLAGMPMOAKS-UHFFFAOYSA-N
ZINC84732511
SCHEMBL1447990
Inchi KeyIUCMLAGMPMOAKS-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H28N4O5S/c1-21(2,3)30-20(26)25-11-9-24(10-12-25)19-22-13-17(14-23-19)29-15-16-5-7-18(8-6-16)31(4,27)28/h5-8,13-14H,9-12,15H2,1-4H3
PubChem CID51029601
ChEMBLCHEMBL2086650
IUPHARN/A
BindingDB50420871
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5041.0 nMPMID23628336, PMID22545772BindingDB,ChEMBL
IC50543.0 nMPMID23628336BindingDB,ChEMBL
Intrinsic activity99.0 %PMID23628336, PMID22545772ChEMBL

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