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Name | Free fatty acid receptor 1 |
---|---|
Species | Mus musculus (Mouse) |
Gene | Ffar1 |
Synonym | FFA1 receptor FFA1R G protein-coupled receptor 40 G-protein coupled receptor 40 GPR40 |
Disease | N/A for non-human GPCRs |
Length | 300 |
Amino acid sequence | MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK |
UniProt | Q76JU9 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5411 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL1777865 |
---|---|
Molecular formula | C23H17F3O3 |
IUPAC name | 3-[4-[4-(trifluoromethyl)naphthalen-1-yl]oxyphenyl]hex-4-ynoic acid |
Molecular weight | 398.381 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 1 |
XlogP | 5.9 |
Synonyms | BDBM50344072 rac-3-(4-(4-(trifluoromethyl)naphthalen-1-yloxy)phenyl)hex-4-ynoic acid |
Inchi Key | IUINAKSQPMKJJM-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C23H17F3O3/c1-2-5-16(14-22(27)28)15-8-10-17(11-9-15)29-21-13-12-20(23(24,25)26)18-6-3-4-7-19(18)21/h3-4,6-13,16H,14H2,1H3,(H,27,28) |
PubChem CID | 54586485 |
ChEMBL | CHEMBL1777865 |
IUPHAR | N/A |
BindingDB | 50344072 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 1248.0 nM | PMID21514824 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218