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GLASS

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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1684030
Molecular formula	C22H32N6O3
IUPAC name	tert-butyl 4-[1-[[2-[4-(tetrazol-1-yl)phenyl]acetyl]amino]propan-2-yl]piperidine-1-carboxylate
Molecular weight	428.537
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.9
Synonyms	BDBM50337890 tert-butyl 4-(1-(2-(4-(1H-tetrazol-1-yl)phenyl)acetamido)propan-2-yl)piperidine-1-carboxylate
Inchi Key	ATSPAYQRYCXFET-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H32N6O3/c1-16(18-9-11-27(12-10-18)21(30)31-22(2,3)4)14-23-20(29)13-17-5-7-19(8-6-17)28-15-24-25-26-28/h5-8,15-16,18H,9-14H2,1-4H3,(H,23,29)
PubChem CID	53317209
ChEMBL	CHEMBL1684030
IUPHAR	N/A
BindingDB	50337890
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	267.0 nM	PMID21310611	BindingDB,ChEMBL
Intrinsic activity	72.0 %	PMID21310611	ChEMBL

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