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GLASS

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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Homo sapiens (Human)
Gene	GPR119
Synonym	GPCR2 GPR119 G-protein coupled receptor 2 G-protein coupled receptor 119 G protein-coupled receptor 119 glucose-dependent insulinotropic receptor [ Show all ]
Disease	Type 2 diabetes Diabetes Peripheral arterial disease; Type 2 diabetes Non-insulin dependent diabetes Gastric cancer; Type 2 diabetes
Length	335
Amino acid sequence	MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
UniProt	Q8TDV5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDV5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDV5.
BioLiP	N/A
Therapeutic Target Database	T93788
ChEMBL	CHEMBL5652
IUPHAR	126
DrugBank	N/A

Ligand

Name	CHEMBL1093453
Molecular formula	C23H38N4O5S
IUPAC name	propan-2-yl 4-[2-[6-(4-propylsulfonylpiperazin-1-yl)pyridin-3-yl]oxyethyl]piperidine-1-carboxylate
Molecular weight	482.64
Hydrogen bond acceptor	8
Hydrogen bond donor	0
XlogP	3.0
Synonyms	BDBM50315164 isopropyl 4-(2-(6-(4-(propylsulfonyl)piperazin-1-yl)pyridin-3-yloxy)ethyl)piperidine-1-carboxylate
Inchi Key	ATWCWUVYNZSTIK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H38N4O5S/c1-4-17-33(29,30)27-14-12-25(13-15-27)22-6-5-21(18-24-22)31-16-9-20-7-10-26(11-8-20)23(28)32-19(2)3/h5-6,18-20H,4,7-17H2,1-3H3
PubChem CID	46885170
ChEMBL	CHEMBL1093453
IUPHAR	N/A
BindingDB	50315164
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	95.0 %	PMID20227877	ChEMBL
EC50	700.0 nM	PMID20227877	BindingDB,ChEMBL

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