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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lutropin-choriogonadotropic hormone receptor
Species	Homo sapiens (Human)
Gene	LHCGR
Synonym	lutropin-choriogonadotropic hormone receptor Luteinizing hormone receptor LSH-R LHR LH/CG-R LH-R LH receptor LGR2 LCGR Choriogonadotropin receptor [ Show all ]
Disease	Heart disease Breast cancer Cancer Myelodysplastic syndrome Female infertility Fertility Leukemia Infertility [ Show all ]
Length	699
Amino acid sequence	MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
UniProt	P22888
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79473
ChEMBL	CHEMBL1854
IUPHAR	N/A
DrugBank	BE0000134

Ligand

Name	SMR000065521
Molecular formula	C17H16N2O4S2
IUPAC name	3,4,5-trimethoxy-N-(4-thiophen-2-yl-1,3-thiazol-2-yl)benzamide
Molecular weight	376.445
Hydrogen bond acceptor	7
Hydrogen bond donor	1
XlogP	3.4
Synonyms	MLS002637011 3,4,5-trimethoxy-N-(4-(thiophen-2-yl)thiazol-2-yl)benzamide BDBM33539 cid_1547871 3,4,5-trimethoxy-N-[4-(2-thienyl)thiazol-2-yl]benzamide MCULE-8504298320 Z28307277 AC1LU5Y6 MolPort-003-009-136 3,4,5-trimethoxy-N-(4-thiophen-2-yl-1,3-thiazol-2-yl)benzamide F0012-0718 SR-01000394670 3,4,5-trimethoxy-N-[4-(thiophen-2-yl)-1,3-thiazol-2-yl]benzamide MLS000055193 ZINC1505628 AKOS003628265 CHEMBL1540513 Oprea1_454021 3,4,5-trimethoxy-N-(4-thiophen-2-yl-2-thiazolyl)benzamide HMS2486E22 SR-01000394670-1 300569-78-2 [ Show all ]
Inchi Key	JAQBWXRSKSVJFG-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H16N2O4S2/c1-21-12-7-10(8-13(22-2)15(12)23-3)16(20)19-17-18-11(9-25-17)14-5-4-6-24-14/h4-9H,1-3H3,(H,18,19,20)
PubChem CID	1547871
ChEMBL	CHEMBL1540513
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	301313.0 nM	PubChem BioAssay data set	ChEMBL

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