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Name | C-X-C chemokine receptor type 1 |
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Species | Homo sapiens (Human) |
Gene | CXCR1 |
Synonym | CDw128a IL8RA IL-8R A IL-8 receptor type I IL-8 receptor type 1 [ Show all ] |
Disease | N/A |
Length | 350 |
Amino acid sequence | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHPNNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCLNPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL |
UniProt | P25024 |
Protein Data Bank | N/A |
GPCR-HGmod model | P25024 |
3D structure model | This predicted structure model is from GPCR-EXP P25024. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4029 |
IUPHAR | 68 |
DrugBank | BE0003552 |
Name | CHEMBL523807 |
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Molecular formula | C19H14Cl2F3N3O5 |
IUPAC name | 3-[[2-[[(1S)-1-(4,5-dichlorofuran-2-yl)-2,2,2-trifluoroethyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide |
Molecular weight | 492.232 |
Hydrogen bond acceptor | 10 |
Hydrogen bond donor | 3 |
XlogP | 4.5 |
Synonyms | BDBM50248501 (S)-3-(2-(1-(4,5-dichlorofuran-2-yl)-2,2,2-trifluoroethylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide |
Inchi Key | JAQGOALYPJHHST-INIZCTEOSA-N |
Inchi ID | InChI=1S/C19H14Cl2F3N3O5/c1-27(2)18(31)7-4-3-5-9(13(7)28)25-11-12(15(30)14(11)29)26-16(19(22,23)24)10-6-8(20)17(21)32-10/h3-6,16,25-26,28H,1-2H3/t16-/m0/s1 |
PubChem CID | 44565099 |
ChEMBL | CHEMBL523807 |
IUPHAR | N/A |
BindingDB | 50248501 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
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Ki | 103.0 nM | PMID19196511 | BindingDB,ChEMBL |
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