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GPCR

NameFollicle-stimulating hormone receptor
SpeciesRattus norvegicus (Rat)
GeneFshr
SynonymFollitropin receptor
FSH receptor
FSH-R
LGR1
DiseaseN/A for non-human GPCRs
Length692
Amino acid sequenceMALLLVSLLAFLGTGSGCHHWLCHCSNRVFLCQDSKVTEIPTDLPRNAIELRFVLTKLRVIPKGSFAGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPSLRYLLISNTGIKHLPAVHKIQSLQKVLLDIQDNINIHIVARNSFMGLSFESVILWLSKNGIEEIHNCAFNGTQLDELNLSDNNNLEELPNDVFQGASGPVILDISRTKVHSLPNHGLENLKKLRARSTYRLKKLPNLDKFVTLMEASLTYPSHCCAFANLKRQISELHPICNKSILRQDIDDMTQIGDQRVSLIDDEPSYGKGSDMMYNEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLECKVQLRHAASVMVLGWTFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMALLVLNVLAFVVICGCYTHIYLTVRNPTIVSSSSDTKIAKRMATLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFILLSKFGCYEMQAQIYRTETSSATHNFHARKSHCSSAPRVTNSYVLVPLNHSSQN
UniProtP20395
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4288
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL192135
Molecular formulaC33H32N2O2
IUPAC nameN-(1-acetyl-2,2,4-trimethyl-4-phenyl-3H-quinolin-6-yl)-4-phenylbenzamide
Molecular weight488.631
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP6.8
Synonyms1-Acetyl-4-phenyl-6-(4-phenylbenzoyl)amino-1,2,3,4-tetrahydro-2,2,4-trimethylquinoline
BDBM50162936
Biphenyl-4-carboxylic acid (1-acetyl-2,2,4-trimethyl-4-phenyl-1,2,3,4-tetrahydro-quinolin-6-yl)-amide
SCHEMBL1323199
AUNHRXZPYDMERZ-UHFFFAOYSA-N
Inchi KeyAUNHRXZPYDMERZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C33H32N2O2/c1-23(36)35-30-20-19-28(21-29(30)33(4,22-32(35,2)3)27-13-9-6-10-14-27)34-31(37)26-17-15-25(16-18-26)24-11-7-5-8-12-24/h5-21H,22H2,1-4H3,(H,34,37)
PubChem CID11260332
ChEMBLCHEMBL192135
IUPHARN/A
BindingDB50162936
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
IC50540.0 nMPMID15771412BindingDB,ChEMBL

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