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GPCR

NameProstaglandin E2 receptor EP4 subtype
SpeciesMus musculus (Mouse)
GenePtger4
SynonymEP2
EP4 receptor
PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
prostanoid EP4 receptor
DiseaseN/A for non-human GPCRs
Length513
Amino acid sequenceMAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTSQTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSHREEPASKGNSLQVTFPSETLKLSEKCI
UniProtP32240
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2489
IUPHAR343
DrugBankN/A

Ligand

NameCHEMBL185277
Molecular formulaC26H31NO5
IUPAC name5-[1-(4-butoxybenzoyl)-5-methoxy-2-methylindol-3-yl]pentanoic acid
Molecular weight437.536
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP6.1
SynonymsBDBM50150976
5-[1-(4-Butoxy-benzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-pentanoic acid
Inchi KeyJDNVFYCHZVXLHI-UHFFFAOYSA-N
Inchi IDInChI=1S/C26H31NO5/c1-4-5-16-32-20-12-10-19(11-13-20)26(30)27-18(2)22(8-6-7-9-25(28)29)23-17-21(31-3)14-15-24(23)27/h10-15,17H,4-9,16H2,1-3H3,(H,28,29)
PubChem CID11282034
ChEMBLCHEMBL185277
IUPHARN/A
BindingDB50150976
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki4200.0 nMPMID15357992BindingDB,ChEMBL

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