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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Histamine H3 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh3
Synonym	GPCR97 H3 receptor H3R HH3R
Disease	N/A for non-human GPCRs
Length	445
Amino acid sequence	MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
UniProt	Q9QYN8
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4124
IUPHAR	264
DrugBank	N/A

Ligand

Name	CHEMBL277537
Molecular formula	C14H16N4O4
IUPAC name	3-(1H-imidazol-5-yl)propyl N-[(3-nitrophenyl)methyl]carbamate
Molecular weight	304.306
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	1.8
Synonyms	(3-Nitro-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester BDBM50051193 3-Nitrobenzylcarbamic acid 3-(1H-imidazol-4-yl)propyl ester
Inchi Key	JEGKJVGFTGBOQM-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H16N4O4/c19-14(22-6-2-4-12-9-15-10-17-12)16-8-11-3-1-5-13(7-11)18(20)21/h1,3,5,7,9-10H,2,4,6,8H2,(H,15,17)(H,16,19)
PubChem CID	10852027
ChEMBL	CHEMBL277537
IUPHAR	N/A
BindingDB	50051193
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	12.59 nM	PMID8676353	BindingDB,ChEMBL
Ki	13.0 nM	PMID8676353	BindingDB,ChEMBL

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