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GLASS

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GPCR

Name	Galanin receptor type 3
Species	Homo sapiens (Human)
Gene	GALR3
Synonym	GAL3-R Galnr3 GALR-3 GALR3 GAL3 receptor
Disease	Cognitive disorders
Length	368
Amino acid sequence	MADAQNISLDSPGSVGAVAVPVVFALIFLLGTVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQATIYTLDAWLFGALVCKAVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALFSAPYLSYYGTVRYGALELCVPAWEDARRRALDVATFAAGYLLPVAVVSLAYGRTLRFLWAAVGPAGAAAAEARRRATGRAGRAMLAVAALYALCWGPHHALILCFWYGRFAFSPATYACRLASHCLAYANSCLNPLVYALASRHFRARFRRLWPCGRRRRHRARRALRRVRPASSGPPGCPGDARPSGRLLAGGGQGPEPREGPVHGGEAARGPE
UniProt	O60755
Protein Data Bank	N/A
GPCR-HGmod model	O60755
3D structure model	This predicted structure model is from GPCR-EXP O60755.
BioLiP	N/A
Therapeutic Target Database	T98494
ChEMBL	CHEMBL2731
IUPHAR	245
DrugBank	N/A

Ligand

Name	MLS003120629
Molecular formula	C23H20N2O4
IUPAC name	N-[(3,4-dimethoxyphenyl)methyl]-3-pyridin-3-yl-1-benzofuran-7-carboxamide
Molecular weight	388.423
Hydrogen bond acceptor	5
Hydrogen bond donor	1
XlogP	3.6
Synonyms	N-[(3,4-dimethoxyphenyl)methyl]-3-(3-pyridinyl)-7-benzofurancarboxamide BDBM97184 cid_49778835 3-(3-pyridyl)-N-veratryl-benzofuran-7-carboxamide N-[(3,4-dimethoxyphenyl)methyl]-3-pyridin-3-yl-1-benzofuran-7-carboxamide SMR001290021 CHEMBL1878609 [ Show all ]
Inchi Key	JFJPHFGNNOUNGZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H20N2O4/c1-27-20-9-8-15(11-21(20)28-2)12-25-23(26)18-7-3-6-17-19(14-29-22(17)18)16-5-4-10-24-13-16/h3-11,13-14H,12H2,1-2H3,(H,25,26)
PubChem CID	49778835
ChEMBL	CHEMBL1878609
IUPHAR	N/A
BindingDB	97184
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	126.34 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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