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GPCR

NameMelanin-concentrating hormone receptor 2
SpeciesHomo sapiens (Human)
GeneMCHR2
SynonymG-protein coupled receptor 145
melanin-concentrating hormone receptor 2
MCHR-2
MCH2R
MCH2 receptor
[ Show all ]
DiseaseN/A
Length340
Amino acid sequenceMNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProtQ969V1
Protein Data BankN/A
GPCR-HGmod modelQ969V1
3D structure modelThis predicted structure model is from GPCR-EXP Q969V1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5038
IUPHAR281
DrugBankN/A

Ligand

NameCHEMBL211311
Molecular formulaC35H31ClFN5O2
IUPAC namebenzyl 4-[[(5-chloro-6-fluoro-1H-benzimidazol-2-yl)methylamino]-[4-(3-cyanophenyl)phenyl]methyl]piperidine-1-carboxylate
Molecular weight608.114
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP6.6
SynonymsBDBM50186775
4-[[(6-chloro-5-fluoro-1H-benzoimidazol-2-ylmethyl)-amino]-(3''-cyano-biphenyl-4-yl)-methyl]-piperidine-1-carboxylic acid benzyl ester
Inchi KeyJFMIBDAAZFALFW-UHFFFAOYSA-N
Inchi IDInChI=1S/C35H31ClFN5O2/c36-29-18-31-32(19-30(29)37)41-33(40-31)21-39-34(26-11-9-25(10-12-26)28-8-4-7-24(17-28)20-38)27-13-15-42(16-14-27)35(43)44-22-23-5-2-1-3-6-23/h1-12,17-19,27,34,39H,13-16,21-22H2,(H,40,41)
PubChem CID44412686
ChEMBLCHEMBL211311
IUPHARN/A
BindingDB50186775
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<3000.0 nMPMID16690312BindingDB,ChEMBL

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