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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Pyroglutamylated RF-amide peptide receptor
Species	Homo sapiens (Human)
Gene	QRFPR
Synonym	QRFP receptor peptide p518 receptor Orexigenic neuropeptide QRFP receptor GPR103 G-protein coupled receptor 103 G protein-coupled receptor 103 AQ27 SP9155 [ Show all ]
Disease	N/A
Length	431
Amino acid sequence	MQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProt	Q96P65
Protein Data Bank	N/A
GPCR-HGmod model	Q96P65
3D structure model	This predicted structure model is from GPCR-EXP Q96P65.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5852
IUPHAR	333
DrugBank	N/A

Ligand

Name	784-90-7
Molecular formula	C12H15N5
IUPAC name	2-(4,6,7-trimethylquinazolin-2-yl)guanidine
Molecular weight	229.287
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	1.5
Synonyms	SR-01000493214-1 AKOS000270442 CTK2F9819 MolPort-000-870-548 Z57093758 2-(4,6,7-trimethylquinazolin-2-yl)guanidine BAS 00501778 Guanidine, (4,6,7-trimethyl-2-quinazolinyl)- R3974 9727AE MCULE-6797855535 SMR000284641 STK033079 (4,6,7-trimethyl-quinazolin-2-yl)-guanidine ALBB-021845 DTXSID30386127 N-(4,6,7-Trimethyl-quinazolin-2-yl)-guanidine ZINC6796972 BDBM50019984 guanidine, N-(4,6,7-trimethyl-2-quinazolinyl)- SBB041927 SR-01000493214 AC1MEDHI CHEMBL528724 MLS000688740 TOS-BB-1276 1-(4,6,7-trimethylquinazolin-2-yl)guanidine amino(4,6,7-trimethylquinazolin-2-yl)carboxamidine GNF-Pf-1241 N-(4,6,7-trimethylquinazolin-2-yl)guanidine ZX-AN037434 C12H15N5 HMS2609K23 SCHEMBL3470079 [ Show all ]
Inchi Key	JFQDHSRWWLJCBV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C12H15N5/c1-6-4-9-8(3)15-12(17-11(13)14)16-10(9)5-7(6)2/h4-5H,1-3H3,(H4,13,14,15,16,17)
PubChem CID	2853458
ChEMBL	CHEMBL528724
IUPHAR	N/A
BindingDB	50019984
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2511.89 nM	PMID24900874	ChEMBL
IC50	2512.0 nM	PMID24900874	BindingDB
IC50	5011.87 nM	PMID24900874	ChEMBL
IC50	5012.0 nM	PMID24900874	BindingDB

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