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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide S receptor
Species	Homo sapiens (Human)
Gene	NPSR1
Synonym	G-protein coupled receptor for asthma susceptibility vasopressin receptor-related receptor 1 G protein-coupled receptor 154 PGR14 NPS receptor G-protein coupled receptor 154 GPR154 G-protein coupled receptor PGR14 VRR1 [ Show all ]
Disease	Neurological disease
Length	371
Amino acid sequence	MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
UniProt	Q6W5P4
Protein Data Bank	N/A
GPCR-HGmod model	Q6W5P4
3D structure model	This predicted structure model is from GPCR-EXP Q6W5P4.
BioLiP	N/A
Therapeutic Target Database	T20958
ChEMBL	CHEMBL5162
IUPHAR	302
DrugBank	BE0000948

Ligand

Name	5-(4-bromophenyl)-N-phenyl-2-furamide
Molecular formula	C17H12BrNO2
IUPAC name	5-(4-bromophenyl)-N-phenylfuran-2-carboxamide
Molecular weight	342.192
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.5
Synonyms	AN-023/13177035 SMR000115154 HMS2405P08 AC1MEIPA MolPort-002-209-585 STL381922 MCULE-8404895948 AKOS002340865 REGID_for_CID_2904011 CHEMBL1611765 ZINC4656196 5-(4-bromophenyl)-N-phenylfuran-2-carboxamide MLS000550092 [ Show all ]
Inchi Key	ACFDHRGCMPAHBH-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H12BrNO2/c18-13-8-6-12(7-9-13)15-10-11-16(21-15)17(20)19-14-4-2-1-3-5-14/h1-11H,(H,19,20)
PubChem CID	2904011
ChEMBL	CHEMBL1611765
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	20.0 nM	PubChem BioAssay data set	ChEMBL

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