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GPCR

Name	D(2) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD2
Synonym	dopamine receptor 2 Dopamine D2 receptor D2R D2A and D_2B D2(415) and D₂₍₄₄₄₎ D2 receptor [ Show all ]
Disease	Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease Inflammatory bowel disease Idiopathic thrombocytopenic purpura Hypertension; Angina pectoris Hypertension Hyperprolactinemia Huntington's disease Glaucoma Gastrointestinal problems Malignant phaeochromocytoma; Benign prostatic hypertrophy; Malignant essential hypertension Migraine headaches Nasal congestion Sexual dysfunction Schizophrenia; Schizoaffective disorders Schizophrenia; Bipolar disorder Schizophrenia Psychotic disorders Psychosis Postpartum haemorrhage Peripheral vasoconstriction; Pulmonary hypertension Parkinson's disease Pain; Inflammatory diseases Ophthalmic disease Non-small cell lung cancer Nausea; Vomiting Fibrosis False perceptions; Bipolar disorder Emesis Chronic obstructive pulmonary disease Cerebrovascular ischaemia Cardiotonic Cardiac failure Bacterial infections Breast cancer Bipolar disorder; Schizophrenia Bipolar disorder Corneal vascularity; Hyperaemia; Itching Asthma; Bronchitis Anxiety disorder Carcinoid syndrome; Acromegaly Advanced stage Parkinson's disease Dermal necrosis Depressive fatigue Alcohol use disorders Allergy Alzheimer disease Hypotension [ Show all ]
Length	443
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProt	P14416
Protein Data Bank	6cm4, 6c38
GPCR-HGmod model	P14416
3D structure model	This structure is from PDB ID 6cm4.
BioLiP	BL0408379, BL0403379
Therapeutic Target Database	T67162
ChEMBL	CHEMBL217
IUPHAR	215
DrugBank	BE0000756

Ligand

Name	disulfiram
Molecular formula	C10H20N2S4
IUPAC name	diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate
Molecular weight	296.524
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.9
Synonyms	AB00051976-21 Exhorran CJ-05170 Nocbin Abstinil HMS1920I16 D00131 NSC-25953 AKOS000120201 HMS3393M17 Disulfide, bis(diethylthiocarbamoyl) Prestwick0_000097 Antabus (TN) I14-53917 Disulfiram, United States Pharmacopeia (USP) Reference Standard Refusal [Netherlands] Antaetil KBioSS_001490 Disulfram Sanceler TET Antiaethan LS-2031 Dupon 4472 SPBio_001191 ANW-40884 N,N',N'-Tetraethylthiuram disulfide Bis((diethylamino)thioxomethyl) disulfide NCGC00016000-02 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane Esperal [France] bis-(diethyl-thiocarbamyl)-disulfide NCGC00016000-10 1-(diethylthiocarbamoyldisulfanyl)-N,N-diethyl-methanethioamide Ethyl Tuex C01692 NCGC00094423-02 Tetraethylthiuram Tetraetil Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), tetraethyl- Tox21_110280_1 TTS x Z-0809 SR-01000076145 Stopetyl Tetidis CCG-39549 NCGC00094423-06 AB00051976_25 Formamide,1'-dithiobis(N,N-diethylthio)- Contrapot Nocceler TET-G AC1Q2YXI HMS2091O22 Dicupral NSC756748 Alk-aubs Hoca Disulfiram (JP17/USP/INN) Prestwick3_000097 Antabuse;Antabus KBio2_001490 Disulfiramo Robac TET Antethyl KS-000046JU DL-379 SBI-0051131.P004 Antiethanol MLS000069818 EINECS 202-607-8 Spectrum2_001176 Aversan N,N,N',N'-Tetraethylthiuram disulphide Ekaland TETD Bis(diethylthiocarbamoyl)disulphide NCGC00016000-05 1,1',1'',1'''-{disulfanediylbis[(thioxomethylene)nitrilo]}tetraethane Ethyl Thiram BPBio1_000060 NCGC00016000-13 ethylthiudad Tetraethylthiuram disulfide, >=97.0% (S) THIOCID Thiuram disulfide, tetraethyl- Tox21_501164 UPCMLD-DP090 SR-01000076145-8 TATD tetraethyl thiuram disulfide NCGC00261849-01 Abstensil GTPL7168 CS-2209 NSC 190940 ACMC-209s92 HMS3263J09 Disulfan Perkait TETD Antab use HSDB 3317 Disulfiram, European Pharmacopoeia (EP) Reference Standard R531 Antaethan KBio3_001150 Disulfiramum [INN-Latin] s1680 Anthethyl Lopac0_001164 DSSTox_RID_76082 SMR000059171 Antivitium MLS001423963 Ekagom TETDS BCP07331 NC00063 1,1''-dithiobis(N,N-diethylthioformamide) Espenal Bis(N,N-diethylthiocarbamoyl) disulfide NCGC00016000-08 1,1;-Dithiobis(N,N-diethylthioformamide Ethyl tuads BSPBio_000054 NCGC00016000-18 AB00051976 EU-0101164 Tetraethylthiram disulfide Tetraethylthiuran disulfide Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetraethyl- Tillram TTD W0030 Spectrum5_001590 Stopethyl tet raethylthiuram AB00051976-23 Formamide, 1,1'-dithiobis(N,N-diethylthio)- CJ-23871 Nocceler Abstinyl HMS2051M17 D0X5SD NSC-756748 Akrochem TETD HMS3655I19 Prestwick1_000097 Antabuse InChI=1/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H Disulfirame Ro-sulfiram Antalcol Krotenal Disulfuram Sanceler TET-G Anticol MCULE-1443050857 Dupont fungicide 4472 SPBio_001993 ARONIS24121 N,N,N'',N''-tetraethylthiuram disulfide Bis((diethylamino)thioxomethyl)disulphide NCGC00016000-03 1,1',1'',1'''-[dithiobis(carbonothioylnitrilo)]tetraethane Eta bus Bis[(diethylamino)thioxomethyl] disulfide NCGC00016000-11 11078-22-1 Ethyldithiourame C10H20N2S4 NCGC00094423-03 Tetraethylthiuram disulfide Teturam Thioperoxydicarbonic diamide, tetraethyl- Tox21_300403 Tuads, ethyl Z1522553469 SR-01000076145-1 SW196492-4 Tetradin CCRIS 582 NCGC00094423-07 AB2000216 FT-0631502 CPD000059171 Noxal Accel TET HMS2095C16 diethylcarbamothioylsulfanyl N,N-diethylcarbamodithioate Opera_ID_224 AN-24463 Hocakrotenalnci-C02959 Disulfiram [USP:INN:BAN:JAN] Prestwick_182 Antadix KBio2_004058 Disulfiramo [INN-Spanish] RTR-030253 Antetil KSC491K6T DSSTox_CID_1322 SC-75356 Antietil MLS000758264 Ekagom DTET Spectrum3_000405 Averzan N,N-diethylcarbamodithioic acid [[diethylamino(sulfanylidene)methyl]thio] ester (diethylamino){[(diethylamino)thioxomethyl]disulfanyl}methane-1-thione ENT 27,340 Bis(diethylthiocarbamyl) disulfide NCGC00016000-06 1,1'-Dithiobis(N,N-diethylthioformamide) Ethyl Thiudad BRD-K32744045-001-05-6 NCGC00016000-14 97-77-8 ethyltuex Tetraethylthiuram disulphide Thioperoxydicarbonic diamide (((H2N)C(S))2S2), N,N,N',N'-tetraethyl- Thiuram E TR-030253 UPCMLD-DP090:001 STL069539 Tenurid Tetraethyldithiuram disulfide AB00051976-20 Exhoran CHEMBL964 NCI-C02959 Abstensyl (Argentina) HMS1568C16 CTK3J1569 NSC 25953 AI3-27340 HMS3371B21 Disulfarim Pharmakon1600-01500262 Antabus HY-B0240 Disulfiram, Pharmaceutical Secondary Standard; Certified Reference Material Refusal Antaethyl KBioGR_000895 Disulfirm SAM001247028 Anti-ethyl LP01164 DTXSID1021322 Soxinol TET Antivitium (Spain) MolPort-001-792-519 BDBM50058655 NCGC00016000-01 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetra Esperal Bis(N,N-diethylthiocarbamoyl)disulphide NCGC00016000-09 1,N-diethylthioformamide] Ethyl Tuads Rodform BSPBio_001930 NCGC00094423-01 Tetraethylthiram disulphide Tetraethylthiurium disulfide Thioperoxydicarbonic diamide ([(H2N)C(S)]2S2), N,N,N',N'-tetraethyl- Tox21_110280 TTS WLN: 2N2 & YUS & S 2 Spectrum_001010 Stopety TETD AB00051976_22 Formamide, 1,1'-dithiobis(N,N-diethylthio- Contralin Nocceler TET AC1L1F7H HMS2090C18 DB00822 NSC25953 Alcophobin HMS3712C16 Disulfiram (Antabuse) Prestwick2_000097 Antabuse (TN) KB-81054 Disulfirame [DCIT] Ro-Sulfram-500 (USA) Antetan KS-000011OS Disulphuram SBB058706 Antietanol MFCD00009048 EC 202-607-8 SPECTRUM1500262 AUZONCFQVSMFAP-UHFFFAOYSA-N N,N,N',N'-Tetraethylthiuram disulfide Bis(diethylthiocarbamoyl) disulfide NCGC00016000-04 1,1',1'',1'''-{disulfanediylbis[(thioxomethylene)-nitrilo]}tetraethane Etabus Bonibal NCGC00016000-12 155-01-1 Ethyldithiurame CAS-97-77-8 NCGC00094423-05 Tetraethylthiuram disulfide, 97% Teturamin Thireranide Tox21_400072 UNII-TR3MLJ1UAI ZINC1529266 SR-01000076145-5 T 1132 Tetradine CHEBI:4659 NCGC00254447-01 Abstenisil Gababentin Cronetal Noxal (VAN) Accel TET-R HMS2230K06 Disetil Perkacit TETD Ancazide ET HS-0057 Disulfiram, British Pharmacopoeia (BP) Reference Standard Q-201812 Antaenyl KBio2_006626 Disulfiramum S00294 Anteyl Lopac-T-1132 DSSTox_GSID_21322 SCHEMBL27213 Antikol MLS001076475 Ekagom TEDS Spectrum4_000228 B0479 N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide 1,1'',1'''',1''''''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane Ephorran Bis(diethylthiocarbamyoyl)disulfide NCGC00016000-07 1,1'-Dithiobis[N,N-diethylthioformamide] Ethyl Thiurad BRD-K32744045-001-17-1 NCGC00016000-15 A845750 Etyl Tuex Tetraethylthiuram sulfide Thioperoxydicarbonic diamide (((H2N)C(S))2S2), tetraethyl- Thiuranide TR3MLJ1UAI Usaf B-33 Stopaethyl Tenutex Tetraethylthioperoxydicarbonic diamide [ Show all ]
Inchi Key	AUZONCFQVSMFAP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
PubChem CID	3117
ChEMBL	CHEMBL964
IUPHAR	N/A
BindingDB	50058655
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	23018.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	7673.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL

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