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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesRattus norvegicus (Rat)
GeneHtr1a
Synonym5-HT1A receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
5-HT1A
ADRB2RL1
ADRBRL1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length422
Amino acid sequenceMDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProtP19327
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL273
IUPHAR1
DrugBankN/A

Ligand

NameBDBM50054356
Molecular formulaC19H25N5O4
IUPAC name1-hydroxy-2-[3-[4-(4-nitrophenyl)piperazin-1-yl]propyl]-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-3-one
Molecular weight387.44
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP1.6
Synonyms2-{3-[4-(4-Nitro-phenyl)-piperazin-1-yl]-propyl}-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione
Inchi KeyACFRJYPCQVVKOZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H25N5O4/c25-18-17-3-1-9-22(17)19(26)23(18)10-2-8-20-11-13-21(14-12-20)15-4-6-16(7-5-15)24(27)28/h4-7,25H,1-3,8-14H2
PubChem CID53635235
ChEMBLN/A
IUPHARN/A
BindingDB50054356
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID8893838BindingDB
Ki168260.0 nMPMID9171874BindingDB

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