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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392142
Molecular formula	C10H5NO6
IUPAC name	8-nitro-4-oxochromene-2-carboxylic acid
Molecular weight	235.151
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	1.5
Synonyms	JNMUUGPMODDSNA-UHFFFAOYSA-N 8-nitro-2-carboxy-4-oxo-4H-1-benzopyran SCHEMBL4250005 8-Nitro-4-oxo-4H-1-benzopyran-2-carboxylic acid BDBM50436038
Inchi Key	JNMUUGPMODDSNA-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H5NO6/c12-7-4-8(10(13)14)17-9-5(7)2-1-3-6(9)11(15)16/h1-4H,(H,13,14)
PubChem CID	21982642
ChEMBL	CHEMBL2392142
IUPHAR	N/A
BindingDB	50436038
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	46300.0 nM	PMID23713606	BindingDB,ChEMBL
Emax	101.0 %	PMID23713606	ChEMBL
Ki	13600.0 nM	PMID23888932	BindingDB,ChEMBL

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