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GPCR

NameNeuropeptide Y receptor type 1
SpeciesCavia porcellus (Guinea pig)
GeneNPY1R
SynonymNPY1-R
DiseaseN/A for non-human GPCRs
Length383
Amino acid sequenceMNSTSFSQLENHSVHYNLSEEKPSFFAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALILIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWIFGEIMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYIGIAVIWVLAVASSLPFMIYQVLTDEPFQNVTLDAFKDKLVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDSKYRSSESKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPLAFKKISCVENEKI
UniProtQ9WVD0
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHARN/A
DrugBankN/A

Ligand

NameNPY, zebrafish
Molecular formulaC192H290N52O58
IUPAC name(4S)-5-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-[[2-[[(2S)-1-[(2S)-4-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoic acid
Molecular weight4254.74
Hydrogen bond acceptor65
Hydrogen bond donor58
XlogP-16.9
SynonymsN/A
Inchi KeyJOHLMVOWAZKKIB-JKQYVYSSSA-N
Inchi IDInChI=1S/C192H290N52O58/c1-17-96(9)151(181(293)233-132(85-143(197)254)172(284)226-127(78-95(7)8)174(286)238-152(97(10)18-2)182(294)240-154(103(16)247)183(295)222-119(34-25-71-208-192(203)204)158(270)220-121(59-63-142(196)253)163(275)218-118(33-24-70-207-191(201)202)161(273)235-136(189(301)302)83-108-47-57-114(252)58-48-108)237-175(287)130(82-107-45-55-113(251)56-46-107)229-171(283)131(84-109-89-205-92-210-109)230-160(272)117(32-23-69-206-190(199)200)219-168(280)126(77-94(5)6)224-157(269)99(12)212-176(288)137(91-245)236-170(282)129(81-106-43-53-112(250)54-44-106)228-169(281)128(80-105-41-51-111(249)52-42-105)227-159(271)116(30-19-21-67-193)216-155(267)98(11)211-166(278)125(76-93(3)4)225-165(277)123(62-66-148(261)262)221-164(276)122(61-65-147(259)260)217-156(268)100(13)213-178(290)139-36-27-72-241(139)185(297)101(14)214-167(279)133(87-149(263)264)231-162(274)120(60-64-146(257)258)215-145(256)90-209-177(289)138-35-26-74-243(138)188(300)135(86-144(198)255)234-173(285)134(88-150(265)266)232-179(291)140-37-29-75-244(140)187(299)124(31-20-22-68-194)223-184(296)153(102(15)246)239-180(292)141-38-28-73-242(141)186(298)115(195)79-104-39-49-110(248)50-40-104/h39-58,89,92-103,115-141,151-154,245-252H,17-38,59-88,90-91,193-195H2,1-16H3,(H2,196,253)(H2,197,254)(H2,198,255)(H,205,210)(H,209,289)(H,211,278)(H,212,288)(H,213,290)(H,214,279)(H,215,256)(H,216,267)(H,217,268)(H,218,275)(H,219,280)(H,220,270)(H,221,276)(H,222,295)(H,223,296)(H,224,269)(H,225,277)(H,226,284)(H,227,271)(H,228,281)(H,229,283)(H,230,272)(H,231,274)(H,232,291)(H,233,293)(H,234,285)(H,235,273)(H,236,282)(H,237,287)(H,238,286)(H,239,292)(H,240,294)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,301,302)(H4,199,200,206)(H4,201,202,207)(H4,203,204,208)/t96-,97-,98-,99-,100-,101-,102?,103+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,151-,152-,153-,154-/m0/s1
PubChem CID57340160
ChEMBLN/A
IUPHARN/A
BindingDB85534
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.066 nMPMID10499421BindingDB

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