You can:
Name | Type-2 angiotensin II receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | AGTR2 |
Synonym | AT2 MRX88 Agtr2 angiotensin II receptor angiotensin II receptor, type 2 [ Show all ] |
Disease | Postherpetic neuralgia Hypertension |
Length | 363 |
Amino acid sequence | MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS |
UniProt | P50052 |
Protein Data Bank | 5xjm, 5unh, 5ung, 5unf |
GPCR-HGmod model | P50052 |
3D structure model | This structure is from PDB ID 5xjm. |
BioLiP | BL0419199, BL0375199,BL0375200, BL0375198, BL0375196,BL0375197 |
Therapeutic Target Database | T09909 |
ChEMBL | CHEMBL4607 |
IUPHAR | 35 |
DrugBank | BE0003426 |
Name | CHEMBL348363 |
---|---|
Molecular formula | C31H28N2O5 |
IUPAC name | 2-(diphenylcarbamoyl)-6-methoxy-5-phenylmethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid |
Molecular weight | 508.574 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 5.4 |
Synonyms | BDBM50282398 5-Benzyloxy-2-diphenylcarbamoyl-6-methoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid |
Inchi Key | AVTOGTIFKTWLLN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C31H28N2O5/c1-37-28-18-17-23-20-32(31(36)33(24-13-7-3-8-14-24)25-15-9-4-10-16-25)27(30(34)35)19-26(23)29(28)38-21-22-11-5-2-6-12-22/h2-18,27H,19-21H2,1H3,(H,34,35) |
PubChem CID | 44371045 |
ChEMBL | CHEMBL348363 |
IUPHAR | N/A |
BindingDB | 50282398 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 5.8 nM | , Bioorg. Med. Chem. Lett., (1994) 4:1:57 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218