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GLASS

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GPCR

Name	Lutropin-choriogonadotropic hormone receptor
Species	Homo sapiens (Human)
Gene	LHCGR
Synonym	lutropin-choriogonadotropic hormone receptor Luteinizing hormone receptor LSH-R LHR LH/CG-R LH-R LH receptor LGR2 LCGR Choriogonadotropin receptor [ Show all ]
Disease	Heart disease Breast cancer Cancer Myelodysplastic syndrome Female infertility Fertility Leukemia Infertility [ Show all ]
Length	699
Amino acid sequence	MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC
UniProt	P22888
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79473
ChEMBL	CHEMBL1854
IUPHAR	N/A
DrugBank	BE0000134

Ligand

Name	MLS000394125
Molecular formula	C22H25N3O5S
IUPAC name	2-butyl-N-[3-(dimethylsulfamoyl)-4-methylphenyl]-1,3-dioxoisoindole-5-carboxamide
Molecular weight	443.518
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.5
Synonyms	CHEMBL1462123 2-butyl-N-[3-(dimethylsulfamoyl)-4-methylphenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxamide Z26500160 AKOS000920146 HMS2511F03 919916-24-8 MolPort-003-199-007 ZINC8692861 MCULE-6980001265 SMR000247719 AB00542596-02 [ Show all ]
Inchi Key	JQECRWINANQWRS-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H25N3O5S/c1-5-6-11-25-21(27)17-10-8-15(12-18(17)22(25)28)20(26)23-16-9-7-14(2)19(13-16)31(29,30)24(3)4/h7-10,12-13H,5-6,11H2,1-4H3,(H,23,26)
PubChem CID	15945376
ChEMBL	CHEMBL1462123
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Potency	169441.0 nM	PubChem BioAssay data set	ChEMBL

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