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Name | Galanin receptor type 2 |
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Species | Homo sapiens (Human) |
Gene | GALR2 |
Synonym | GAL2 receptor GAL2-R GALNR2 GALR-2 |
Disease | N/A |
Length | 387 |
Amino acid sequence | MNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA |
UniProt | O43603 |
Protein Data Bank | N/A |
GPCR-HGmod model | O43603 |
3D structure model | This predicted structure model is from GPCR-EXP O43603. |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL3176 |
IUPHAR | 244 |
DrugBank | N/A |
Name | CHEMBL1922003 |
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Molecular formula | C27H31F4N7 |
IUPAC name | N-(3-fluoro-2-methylphenyl)-6-piperidin-1-yl-2-[4-[3-(trifluoromethyl)pyridin-2-yl]-1,4-diazepan-1-yl]pyrimidin-4-amine |
Molecular weight | 529.588 |
Hydrogen bond acceptor | 11 |
Hydrogen bond donor | 1 |
XlogP | 6.4 |
Synonyms | BDBM50358662 SCHEMBL10144200 |
Inchi Key | JQZOIEVXGHBFNL-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C27H31F4N7/c1-19-21(28)9-5-10-22(19)33-23-18-24(36-12-3-2-4-13-36)35-26(34-23)38-15-7-14-37(16-17-38)25-20(27(29,30)31)8-6-11-32-25/h5-6,8-11,18H,2-4,7,12-17H2,1H3,(H,33,34,35) |
PubChem CID | 57394238 |
ChEMBL | CHEMBL1922003 |
IUPHAR | N/A |
BindingDB | 50358662 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 560.0 nM | PMID22018787 | BindingDB,ChEMBL |
Inhibition | <50.0 % | PMID22018787 | ChEMBL |
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