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GPCR

Name	G-protein coupled receptor 182
Species	Homo sapiens (Human)
Gene	GPR182
Synonym	NOW L1-R GPR182 Gpcr22 Gpcr17 adrenomedullin receptor ADMR [ Show all ]
Disease	N/A
Length	404
Amino acid sequence	MSVKPSWGPGPSEGVTAVPTSDLGEIHNWTELLDLFNHTLSECHVELSQSTKRVVLFALYLAMFVVGLVENLLVICVNWRGSGRAGLMNLYILNMAIADLGIVLSLPVWMLEVTLDYTWLWGSFSCRFTHYFYFVNMYSSIFFLVCLSVDRYVTLTSASPSWQRYQHRVRRAMCAGIWVLSAIIPLPEVVHIQLVEGPEPMCLFMAPFETYSTWALAVALSTTILGFLLPFPLITVFNVLTACRLRQPGQPKSRRHCLLLCAYVAVFVMCWLPYHVTLLLLTLHGTHISLHCHLVHLLYFFYDVIDCFSMLHCVINPILYNFLSPHFRGRLLNAVVHYLPKDQTKAGTCASSSSCSTQHSIIITKGDSQPAAAAPHPEPSLSFQAHHLLPNTSPISPTQPLTPS
UniProt	O15218
Protein Data Bank	N/A
GPCR-HGmod model	O15218
3D structure model	This predicted structure model is from GPCR-EXP O15218.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4356
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	MLS001219965
Molecular formula	C22H26N4O6
IUPAC name	1-N',6-N'-bis(2-phenoxyacetyl)hexanedihydrazide
Molecular weight	442.472
Hydrogen bond acceptor	6
Hydrogen bond donor	4
XlogP	1.9
Synonyms	BAS 00632602 N1'',N6''-bis(2-phenoxyethanoyl)hexanedihydrazide SR-01000321189-1 1-N',6-N'-bis(2-phenoxyacetyl)hexanedihydrazide CHEMBL195258 N'1,N'6-bis(phenoxyacetyl)hexanedihydrazide ZINC8396581 AN-329/11284456 KS-00004CQZ N1'',N6''-bis(1-oxo-2-phenoxyethyl)hexanedihydrazide BDBM75668 MolPort-001-026-535 SMR000608010 ST040593 AC1MJK5S cid_3113773 N'~1~,N'~6~-bis(phenoxyacetyl)hexanedihydrazide ARONIS021213 MCULE-7355707109 N1'',N6''-bis(2-phenoxyacetyl)adipohydrazide SR-01000321189 1-N'',6-N''-bis(2-phenoxyacetyl)hexanedihydrazide N'-{6-oxo-6-[2-(phenoxyacetyl)hydrazino]hexanoyl}-2-phenoxyacetohydrazide STK031740 AKOS000487598 KB-104069 N-(2-phenoxyacetylamino)-N'-(2-phenoxyacetylamino)hexane-1,6-diamide [ Show all ]
Inchi Key	JRJOEGZZOWPWDI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H26N4O6/c27-19(23-25-21(29)15-31-17-9-3-1-4-10-17)13-7-8-14-20(28)24-26-22(30)16-32-18-11-5-2-6-12-18/h1-6,9-12H,7-8,13-16H2,(H,23,27)(H,24,28)(H,25,29)(H,26,30)
PubChem CID	3113773
ChEMBL	CHEMBL195258
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Affinity	1.0 %	PMID15943480	ChEMBL

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