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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Mus musculus (Mouse)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 Serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProt	P35363
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5377
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SR-01000446204
Molecular formula	C19H25N3O3
IUPAC name	1-(3-methoxyphenoxy)-3-(4-pyridin-2-ylpiperazin-1-yl)propan-2-ol
Molecular weight	343.427
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.1
Synonyms	MolPort-000-417-116 AKOS016287057 SR-01000446204-3 1-(3-methoxyphenoxy)-3-[4-(2-pyridyl)piperazino]propan-2-ol cid_2770277 AC1MCI8Y Oprea1_015014 1-(3-methoxyphenoxy)-3-(4-pyridin-2-ylpiperazin-1-yl)propan-2-ol BDBM114599 STL227989 1-(3-methoxyphenoxy)-3-[4-(pyridin-2-yl)piperazin-1-yl]propan-2-ol MCULE-6234794447 AKOS002160762 1-(3-methoxyphenoxy)-3-[4-(2-pyridinyl)-1-piperazinyl]-2-propanol CHEMBL1740242 [ Show all ]
Inchi Key	JRPAOAIMEPGWPZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25N3O3/c1-24-17-5-4-6-18(13-17)25-15-16(23)14-21-9-11-22(12-10-21)19-7-2-3-8-20-19/h2-8,13,16,23H,9-12,14-15H2,1H3
PubChem CID	2770277
ChEMBL	N/A
IUPHAR	N/A
BindingDB	114599
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	76083.0 nM	N/A	BindingDB

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