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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesHomo sapiens (Human)
GeneHTR4
Synonym5-HT-4
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
5-HT4 receptor
5-HT4
serotonin receptor 4
DiseaseN/A
Length388
Amino acid sequenceMDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProtQ13639
Protein Data BankN/A
GPCR-HGmod modelQ13639
3D structure modelThis predicted structure model is from GPCR-EXP Q13639.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1875
IUPHAR9
DrugBankBE0000084

Ligand

Name5-METHOXYTRYPTAMINE
Molecular formulaC11H14N2O
IUPAC name2-(5-methoxy-1H-indol-3-yl)ethanamine
Molecular weight190.246
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP0.5
SynonymsAB00463
Methoxytryptamine
AJ-09618
NCGC00015694-01
BB 0253965
[ Show all ]
Inchi KeyJTEJPPKMYBDEMY-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3
PubChem CID1833
ChEMBLCHEMBL8165
IUPHAR107
BindingDB82087
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Activity100.0 %PMID19223092ChEMBL
Ki26.92 nMPMID19223092BindingDB,ChEMBL
Ki154.88 nMPMID9351641PDSP,BindingDB
Ki158.489 - 2511.89 nMPMID9349523, PMID9603189, PMID10646498, PMID11218067, PMID10683202, PMID11030734IUPHAR
Ki245.47 nMPMID19223092BindingDB,ChEMBL
Ki251.2 nMPMID11218067BindingDB
Ki316.2 nMPMID11218067BindingDB
Ki501.18 nMPMID9349523, PMID8867105PDSP,BindingDB
Ki553.0 nMPMID9603189BindingDB
Ki794.32 nMPMID10646498BindingDB
Ki1000.0 nMPMID10646498, PMID9349523PDSP,BindingDB
Ki1020.0 nMPMID9603189BindingDB
Ki2080.0 nMPMID9603189BindingDB
Ki2443.0 nMPMID9603189BindingDB

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