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GLASS

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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Homo sapiens (Human)
Gene	GHSR
Synonym	ghrelin receptor GH-releasing peptide receptor GHRP GHS-R growth hormone-releasing peptide receptor ghrelin receptor 1a [ Show all ]
Disease	N/A
Length	366
Amino acid sequence	MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
UniProt	Q92847
Protein Data Bank	N/A
GPCR-HGmod model	Q92847
3D structure model	This predicted structure model is from GPCR-EXP Q92847.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4616
IUPHAR	246
DrugBank	BE0003383

Ligand

Name	CHEMBL2048808
Molecular formula	C23H28N2O3
IUPAC name	1-(2-benzyl-2,7-diazaspiro[3.5]nonan-7-yl)-2-(4-methoxyphenoxy)ethanone
Molecular weight	380.488
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	3.3
Synonyms	BDBM50386943
Inchi Key	AWIDXSUFNLMVFO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H28N2O3/c1-27-20-7-9-21(10-8-20)28-16-22(26)25-13-11-23(12-14-25)17-24(18-23)15-19-5-3-2-4-6-19/h2-10H,11-18H2,1H3
PubChem CID	70694647
ChEMBL	CHEMBL2048808
IUPHAR	N/A
BindingDB	50386943
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	2980.0 nM	PMID22677316	BindingDB,ChEMBL
Inhibition	-22.0 %	PMID22677316	ChEMBL

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