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GPCR

NameMuscarinic acetylcholine receptor M2
SpeciesSus scrofa (Pig)
GeneCHRM2
SynonymN/A
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMNNSTNSSNSGLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQEPVSPSLVQGRIVKPNNNNMPGSDEALEHNKIQNGKAPRDAVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIKIVTKTQKSDSCTPANTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
UniProtP06199
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4781
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL303002
Molecular formulaC32H48N4O2+2
IUPAC name6-[dimethyl-[3-(3-oxo-1H-isoindol-2-yl)propyl]azaniumyl]hexyl-dimethyl-[3-(3-oxo-1H-isoindol-2-yl)propyl]azanium
Molecular weight520.762
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP3.9
SynonymsBDBM50408912
CHEMBL31162
Hexamethylenebis[[3-(1-oxoisoindoline-2-yl)propyl]dimethylaminium]
Inchi KeyJXTFRADQSSIBFG-UHFFFAOYSA-N
Inchi IDInChI=1S/C32H48N4O2/c1-35(2,23-13-19-33-25-27-15-7-9-17-29(27)31(33)37)21-11-5-6-12-22-36(3,4)24-14-20-34-26-28-16-8-10-18-30(28)32(34)38/h7-10,15-18H,5-6,11-14,19-26H2,1-4H3/q+2
PubChem CID10604576
ChEMBLCHEMBL31162
IUPHARN/A
BindingDB50408912
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC501995.26 nMPMID12672239, PMID10841794BindingDB,ChEMBL

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