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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	NAPTALAM
Molecular formula	C18H13NO3
IUPAC name	2-(naphthalen-1-ylcarbamoyl)benzoic acid
Molecular weight	291.306
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.5
Synonyms	N-1-Naphthalenephthalamic acid acp322 N-Naphthalen-1-yl-phthalamic acid Alanap 10G Naptalam, analytical standard Alanape NPA,(-) Benzoic acid, 2-((1-naphthalenylamino)carbonyl)- Peach-Thin Caswell No. 592 SCHEMBL54940 DSSTox_RID_78947 WLN: L66J BMVR BVQ HMS1414N13 1-(N-Naphthyl)Phthalamic acid KS-000013CA 2-((1-naphthalenylamino)carbonyl)benzoicacid Mor-Cran 2-[N-(1-naphthylcarbamoyl)]benzoic acid N-1-Naphthylphthalamate AJ-08466 Naftalam [Czech] Alanap Plus Naptalame [ISO-French] Ancrack NSC204421 Benzoic acid, 2-[(1-naphthalenylamino)carbonyl]- (9CI) Phthalamic acid, N-1-naphthyl- (7CI,8CI) CHEMBL2447888 SR-01000392378-1 EPA Pesticide Chemical Code 030702 IFLab1_001003 112284-33-0 Kyselina N-1-naftylftalamova [Czech] 2-(N-naphthylcarbamoyl)benzoic acid N-(1-naphthalenyl)phthalamic acid 6Q8 ZINC28113 ACMC-209bpp N-1-napthylphthalamic acid Alanap alanap10g Nip-a-thin BB0274029 Oprea1_469302 C18869 RTR-004458 DSSTox_CID_12437 Tox21_302279 FT-0629075 JXTHEWSKYLZVJC-UHFFFAOYSA- 2-((1-naphthalenylamino)carbonyl)-benzoicaci MCULE-3496128683 2-[(1-Naphthylamino)carbonyl]benzoic acid N-(1-Naphthyl)phthalamidic acid N-1-Naphthyl-phthalamidsaeure AE-017/30049056 N0067 Alanap 10G at Naptalam, PESTANAL(R), analytical standard alpha-Naphthylphthalamic acid NSC 204421 Benzoic acid, 2-((1-naphthalenylamino)carbonyl)- (9CI) Phthalamic acid, N-1-naphthyl CBDivE_002040 Solo (Salt/Mix) DTXSID6032437 HSDB 1742 1-N-Naphthylphthalamic acid KS-00004AUE 2-((1-Naphthalenylamino)carbonylbenzoic acid N - (1 - Naphthyl)phthalamic acid 3-12-00-02876 (Beilstein Handbook Reference) N-1-Naphthylphthalamic acid AK-57895 Naphthalam Alanap-2 Naptro ANW-19451 NSC_8594 Benzoic acid, 2-[(naphthalenylamino)carbonyl]- Phthalamic acid,N-1-naphthyl- CTK0D2202 ST001288 F0290-1094 InChI=1/C18H13NO3/c20-17(14-9-3-4-10-15(14)18(21)22)19-16-11-5-7-12-6-1-2-8-13(12)16/h1-11H,(H,19,20)(H,21,22) 132-66-1 L001060 2-(naphthalen-1-ylcarbamoyl)benzoic acid N-(1-Naphthyl)phthalamic acid [3H]-NPA ACP 322 N-alpha-Naphthylphthalamic acid Alanap 1 Naptalam [BSI:ISO] alanap10gat NPA (VAN) BDBM81777 Peach Thin 322 CAS-132-66-1 SBB008186 DSSTox_GSID_32437 UNII-306R88V86P Grelutin .alpha.-Naphthylphthalamic acid JXTHEWSKYLZVJC-UHFFFAOYSA-N 2-((1-Naphthalenylamino)carbonyl)benzoic acid MolPort-000-389-108 2-[(1-Naphthylamino)carbonyl]benzoic acid # N-.alpha.-Naphthylphthalamic acid N-1-Naphthyl-phthalamidsaeure [German] AI3-23463 Naftalam Alanap 3 Naptalame Analape NSC-204421 Benzoic acid, 2-[(1-naphthalenylamino)carbonyl]- Phthalamic acid, N-1-naphthyl- CHEBI:60833 SR-01000392378 Dyanap I14-18114 1-Naphthylphthalamic acid Kyselina N-1-naftylftalamova 2-(1-Naphthylcarbamoyl)benzoic acid N-(.alpha.-Naphthyl)phthalamic acid 306R88V86P AC1L1RBG N-1-Naphthylphthalamidic acid AKOS000485934 Naphthylphthalamic acid alanap1 NCGC00255281-01 ARONIS018728 Oprea1_065903 BRN 2814102 Premerge plus (Salt/Mix) Cyanap STK072761 FR-1032 J-006203 132-67-2 (hydrochloride salt) LS-109086 2-[(1-Naphthalenylamino)carbonylbenzoic acid N-(1-Naphthyl)phthalamicAcid [ Show all ]
Inchi Key	JXTHEWSKYLZVJC-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H13NO3/c20-17(14-9-3-4-10-15(14)18(21)22)19-16-11-5-7-12-6-1-2-8-13(12)16/h1-11H,(H,19,20)(H,21,22)
PubChem CID	8594
ChEMBL	N/A
IUPHAR	N/A
BindingDB	81777
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4.0 nM	PMID8097160	PDSP,BindingDB
Ki	13.0 nM	PMID8097160	PDSP
Ki	120.2 nM	PMID8102973	PDSP,BindingDB

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