You can:
Name | Orexin receptor type 1 |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Hcrtr1 |
Synonym | hypocretin (orexin) receptor 1 hypocretin receptor 1 Hypocretin receptor type 1 Hctr1 orexin receptor type 1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 416 |
Amino acid sequence | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS |
UniProt | P56718 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1075232 |
IUPHAR | 321 |
DrugBank | N/A |
Name | SCHEMBL1716852 |
---|---|
Molecular formula | C22H23FN4O2 |
IUPAC name | [(2R,5R)-5-[(5-fluoropyridin-2-yl)oxymethyl]-2-methylpiperidin-1-yl]-(2-pyrazol-1-ylphenyl)methanone |
Molecular weight | 394.45 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 0 |
XlogP | 3.6 |
Synonyms | CHEMBL3655681 BDBM104708 US8569311, 1-37 |
Inchi Key | JZFNVTJQHXSBPW-IAGOWNOFSA-N |
Inchi ID | InChI=1S/C22H23FN4O2/c1-16-7-8-17(15-29-21-10-9-18(23)13-24-21)14-26(16)22(28)19-5-2-3-6-20(19)27-12-4-11-25-27/h2-6,9-13,16-17H,7-8,14-15H2,1H3/t16-,17-/m1/s1 |
PubChem CID | 59396036 |
ChEMBL | CHEMBL3655681 |
IUPHAR | N/A |
BindingDB | 104708 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 55.0 nM | , None | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218