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GPCR

NameEndothelin-1 receptor
SpeciesRattus norvegicus (Rat)
GeneEdnra
Synonymendothelin A receptor
Endothelin receptor type A {ECO:0000312|RGD:2535}
ENDOR
endothelin-1 receptor
ET-A
[ Show all ]
DiseaseN/A for non-human GPCRs
Length426
Amino acid sequenceMGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
UniProtP26684
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4566
IUPHAR219
DrugBankN/A

Ligand

NameCHEMBL30075
Molecular formulaC15H15N3O3S
IUPAC name6-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)naphthalene-2-sulfonamide
Molecular weight317.363
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.3
SynonymsL009162
SCHEMBL8784519
6-Amino-naphthalene-2-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide
BDBM50034436
Inchi KeyAXCASGWUQSFEJM-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H15N3O3S/c1-9-10(2)17-21-15(9)18-22(19,20)14-6-4-11-7-13(16)5-3-12(11)8-14/h3-8,18H,16H2,1-2H3
PubChem CID10403526
ChEMBLCHEMBL30075
IUPHARN/A
BindingDB50034436
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50600.0 nMPMID7861414BindingDB,ChEMBL
IC50660.0 nMPMID7731020ChEMBL
IC50660.0 nMPMID7731020BindingDB

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