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Name | Lutropin-choriogonadotropic hormone receptor |
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Species | Homo sapiens (Human) |
Gene | LHCGR |
Synonym | lutropin-choriogonadotropic hormone receptor Luteinizing hormone receptor LSH-R LHR LH/CG-R [ Show all ] |
Disease | Heart disease Breast cancer Cancer Myelodysplastic syndrome Female infertility [ Show all ] |
Length | 699 |
Amino acid sequence | MKQRFSALQLLKLLLLLQPPLPRALREALCPEPCNCVPDGALRCPGPTAGLTRLSLAYLPVKVIPSQAFRGLNEVIKIEISQIDSLERIEANAFDNLLNLSEILIQNTKNLRYIEPGAFINLPRLKYLSICNTGIRKFPDVTKVFSSESNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLTSLELKENVHLEKMHNGAFRGATGPKTLDISSTKLQALPSYGLESIQRLIATSSYSLKKLPSRETFVNLLEATLTYPSHCCAFRNLPTKEQNFSHSISENFSKQCESTVRKVNNKTLYSSMLAESELSGWDYEYGFCLPKTPRCAPEPDAFNPCEDIMGYDFLRVLIWLINILAIMGNMTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCSTAGFFTVFASELSVYTLTVITLERWHTITYAIHLDQKLRLRHAILIMLGGWLFSSLIAMLPLVGVSNYMKVSICFPMDVETTLSQVYILTILILNVVAFFIICACYIKIYFAVRNPELMATNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKVLLVLFYPINSCANPFLYAIFTKTFQRDFFLLLSKFGCCKRRAELYRRKDFSAYTSNCKNGFTGSNKPSQSTLKLSTLHCQGTALLDKTRYTEC |
UniProt | P22888 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | T79473 |
ChEMBL | CHEMBL1854 |
IUPHAR | N/A |
DrugBank | BE0000134 |
Name | CHEMBL247945 |
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Molecular formula | C38H35N5O3 |
IUPAC name | N-[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-[2-(4-tert-butylphenyl)-5-isoquinolin-3-ylpyrazol-3-yl]benzamide |
Molecular weight | 609.73 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 3 |
XlogP | 7.0 |
Synonyms | SCHEMBL4944493 BDBM50206400 N-((S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-3-(1-(4-tert-butylphenyl)-3-(isoquinolin-3-yl)-1H-pyrazol-5-yl)benzamide |
Inchi Key | KEUNWJNSNZWHBS-UMSFTDKQSA-N |
Inchi ID | InChI=1S/C38H35N5O3/c1-38(2,3)29-13-15-30(16-14-29)43-35(22-33(42-43)32-21-25-7-4-5-8-28(25)23-40-32)26-9-6-10-27(20-26)37(46)41-34(36(39)45)19-24-11-17-31(44)18-12-24/h4-18,20-23,34,44H,19H2,1-3H3,(H2,39,45)(H,41,46)/t34-/m0/s1 |
PubChem CID | 44440748 |
ChEMBL | CHEMBL247945 |
IUPHAR | N/A |
BindingDB | 50206400 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Activity | 19.0 % | PMID17321742 | ChEMBL |
EC50 | 500.0 nM | PMID17321742 | BindingDB,ChEMBL |
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