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Name | Substance-K receptor |
---|---|
Species | Mesocricetus auratus (Golden hamster) |
Gene | TACR2 |
Synonym | Neurokinin A receptor NK-2 receptor NK-2R SKR Tachykinin receptor 2 |
Disease | N/A for non-human GPCRs |
Length | 384 |
Amino acid sequence | MGGRAIVTDTNIFSGLESNTTGVTAFSMPAWQLALWATAYLGLVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPITKATIAGIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFVLVYFLPLVVMFVAYSVIGLTLWKRAVPRHQAHGANLRHLHAKKKFVKAMVLVVLTFAICWLPYHLYFILGSFQKDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTRTPSLSRRVNRCHTKETLFMTADMTHSEATNGQVGSPQDVEPAAP |
UniProt | P51144 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL2304405 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL346633 |
---|---|
Molecular formula | C28H32N2 |
IUPAC name | (2R,3R)-2-benzhydryl-N-[(2-methylphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine |
Molecular weight | 396.578 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 1 |
XlogP | 5.8 |
Synonyms | BDBM50280469 [(2R,3R)-2-(2,2-Diphenyl-ethyl)-1-aza-bicyclo[2.2.2]oct-3-yl]-(2-methyl-benzyl)-amine |
Inchi Key | KHWRHXNNDGPGGG-VSGBNLITSA-N |
Inchi ID | InChI=1S/C28H32N2/c1-21-10-8-9-15-25(21)20-29-27-24-16-18-30(19-17-24)28(27)26(22-11-4-2-5-12-22)23-13-6-3-7-14-23/h2-15,24,26-29H,16-20H2,1H3/t27-,28-/m1/s1 |
PubChem CID | 15037919 |
ChEMBL | CHEMBL346633 |
IUPHAR | N/A |
BindingDB | 50280469 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 100000.0 nM | Bioorg. Med. Chem. Lett., (1992) 2:6:559 | ChEMBL |
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