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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Mus musculus (Mouse)
Gene	Mchr1
Synonym	SLC-1 {ECO:0000303\|PubMed:11159839} MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 somatostatin receptor-like protein [ Show all ]
Disease	N/A for non-human GPCRs
Length	353
Amino acid sequence	MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProt	Q8JZL2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4730
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL197054
Molecular formula	C28H30N6O3
IUPAC name	1-[2-[5-[(4-phenoxyphenyl)carbamoylamino]indazol-1-yl]ethyl]piperidine-4-carboxamide
Molecular weight	498.587
Hydrogen bond acceptor	5
Hydrogen bond donor	3
XlogP	3.0
Synonyms	1-(2-{5-[3-(4-Phenoxy-phenyl)-ureido]-indazol-1-yl}-ethyl)-piperidine-4-carboxylic acid amide BDBM50167571 SCHEMBL6070026
Inchi Key	KIOITPZEEHNURK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H30N6O3/c29-27(35)20-12-14-33(15-13-20)16-17-34-26-11-8-23(18-21(26)19-30-34)32-28(36)31-22-6-9-25(10-7-22)37-24-4-2-1-3-5-24/h1-11,18-20H,12-17H2,(H2,29,35)(H2,31,32,36)
PubChem CID	11386451
ChEMBL	CHEMBL197054
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	134.0 nM	PMID15911251	ChEMBL

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