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GPCR

NameFree fatty acid receptor 1
SpeciesMus musculus (Mouse)
GeneFfar1
SynonymFFA1 receptor
FFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
DiseaseN/A for non-human GPCRs
Length300
Amino acid sequenceMDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK
UniProtQ76JU9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5411
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1777866
Molecular formulaC18H13ClF3NO3
IUPAC name3-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]hex-4-ynoic acid
Molecular weight383.751
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP4.6
SynonymsBDBM50344073
rac-3-(4-(3-chloro-5-(trifluoromethyl)pyridin-2-yloxy)phenyl)hex-4-ynoic acid
Inchi KeyKJKPJGXGFQYFKV-UHFFFAOYSA-N
Inchi IDInChI=1S/C18H13ClF3NO3/c1-2-3-12(8-16(24)25)11-4-6-14(7-5-11)26-17-15(19)9-13(10-23-17)18(20,21)22/h4-7,9-10,12H,8H2,1H3,(H,24,25)
PubChem CID54582630
ChEMBLCHEMBL1777866
IUPHARN/A
BindingDB50344073
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5095.0 nMPMID21514824BindingDB,ChEMBL

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